Browsing Faculty of Natural Science by Author "Egieyeh, Samuel"
Now showing items 1-9 of 9
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Cheminformatic Approaches to Hit-Prioritization and Target Prediction of Potential Anti-MRSA Natural Products
Oselusi, Samson Olaitan (University of the Western Cape, 2020)The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ... -
Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products
Oselusi, Samson Olaitan (University of Western Cape, 2020)The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ... -
Feasibility of an internationally recognized conformitè europëenne equivalent mark for medical devices in africa: a review of current literature
Nkuku, Khanyisile Zachia (University of the Western cape, 2024)Medical devices are crucial to health systems and are critical to addressing the disease burden of African countries. In light of the importance of diagnosis and surgical intervention in healthcare, medical devices such ... -
Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
Omotoso, Christianah Taye (University of the Western Cape, 2022)The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual genetic variations in drug-metabolising enzymes. Cytochrome P450 enzymes constitute the major metabolising enzymes in humans. ... -
Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
Ilori, Tosin Lydia (University of the Western Cape, 2023)One of the crucial ways by which Staphylococcus aureus develops resistance to antibiotics is biofilm formation, a protective mechanism involving extracellular polymeric substance (EPS) matrix that shields microorganisms ... -
Knowledge, perceptions and practices of risk-based monitoring among clinical practitioners in the United States
Hockin, Jennifer (University of the Western Cape, 2018)This study investigated the current knowledge, perceptions, and practices of Risk-Based Monitoring (RBM) using written and verbal responses to an ethics review board approved questionnaire. Responses were collected from ... -
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
Pokomi, Rostand Fankam (University of the Western Cape, 2020)Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ... -
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
Oladunjoye, Bolu Bimbola (University of the Western Cape, 2021)Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ... -
The transition of regulatory services from drug regulatory unit to Botswana medicines regulatory authority: an evaluation of the changes in regulatory services from the industry’s perspective
Maloisane, Rebecca M (University of the Western Cape, 2023)The Drug Regulatory Unit (DRU) was established by the Ministry of Health (MoH) to enforce the Drugs and Related Substances Act of 1992 in line with the Botswana National Drug Policy (BNDP) adopted in 2002 and the National ...