Browsing Faculty of Natural Science by Subject "Oxidative stress"
Now showing items 1-20 of 20
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The antioxidant properties of melatonin during chemical hypoxia and reoxygenation injury in rat ventricular myocytes
(University of the Western Cape, 2000)It is well known that ischaemia chemical hypoxia followed by reperfusion is not always accompanied by recovery of myocardial function and often produces further cell damage (Hearse et al., 1973). This phenomenon commonly ... -
Biocontrol potential of fungal endophytes against Fusarium proliferatum in maize
(University of the Western Cape, 2022)Fusarium proliferatum is a fungal pathogen that is the cause of numerous diseases in various crops of fruit and vegetables. About 25% of the maize crops harvested annually are affected by mycotoxins produced by F. ... -
Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
(University of the Western Cape, 2020)Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that has an insidious onset and diagnosed when ... -
Chemical isolation and electro-chemical characterization of antidiabetic compounds from selected South African lamiaceae plant species
(University of the Western Cape, 2020)Diabetes mellitus (DM), being one of the most common metabolic disorders with an elevated morbidity and mortality rate around the world. It is characterised by deficiency in insulin secretion or degradation of secreted ... -
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ... -
The effects of silver nanoparticles on the expression of protein biomarkers of cell stress, apoptosis and inflammation by the human liver cancer cell line, HepG2
(University of Western Cape, 2021)Nanoscience is the study of phenomena and objects at the nanoscale (around 1-100 nm), socalled nanomaterials. These nanomaterials exhibit novel properties that are often very different to those of the bulk materials used ... -
Evaluation of the antioxidant and anti-diabesity potential of cyclopia maculata using in vitro non-cell based screening models
(University of the Western Cape, 2014)The aim of this study was therefore to evaluate the antioxidant and anti-diabesity potential of a hot water extract of C. maculata in non-cell based assays and correlate the activities with phenolic composition. Total ... -
The impact of different storage temperatures and storage period on the antioxidant activity of pomegranate
(University of Western Cape, 2021)Fruit storage at cold temperatures is normally used to delay decay while maintaining the fruit’s quality. However, storage at low temperatures for a prolonged period causes some important metabolic functions within the ... -
Influence of a selected endophyte consortium on salinity responses in Medicago sativa
(University of Western Cape, 2022)Salinity is one of the major limiting factors to crop production, which consequently contributes to the risk of reduced food security. Among other factors, food security depends on availability of sufficient and nutritious ... -
Isolation and Bioassay evaluation of Angiotensin Converting Enzyme inhibitory compounds of Centella asiatica
(University of the Western Cape, 2019)Hypertension is by far the most common risk factor for cardiovascular disease (CVD), which has been identified as the leading cause of death worldwide and a major economic burden in developing countries. Over the years, ... -
Novel norbornane derivatives as potential neuroprotective agents
(University of Western Cape, 2020)Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological functions as a result of gradual degeneration of neurons in the central nervous system. Even though they are classified as ... -
Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
(University of the Western Cape, 2014)This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the ... -
Phytochemical and biological studies of Helichrysum cymosum
(University of the Western Cape, 2020)Diabetes mellitus (DM) is well known as a group of systemic metabolic disorders with a considerable mortality rate around the world. Hyperglycemia is the main consequence of DM, which results from the shortage in insulin ... -
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ... -
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
(University of the Western Cape, 2018)Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ... -
Premature aging of the lungs of the offspring induced by maternal nicotine exposure during gestation and lactation: protective effects of tomato juice
(University of the Western Cape, 2012)exposed to nicotine through the blood and the milk of the mother. Nicotine is thus expected to interact with the developing fetus and the offspring of mothers who smoke or use NRT for smoking cessation, resulting in the ... -
Responses of maize Antioxidant Enzymes to drought stress
(University of the Western Cape, 2019)Maize (Zea mays L) was subjected to drought stress for 28 days. The effects of the drought stress on growth, H2O2 content and lipid peroxidation were investigated and the activities of antioxidant enzymes [superoxide ... -
Responses of maize antioxidant enzymes to drought stress
(University of the Western Cape, 2019)Maize (Zea mays L) was subjected to drought stress for 28 days. The effects of the drought stress on growth, H2O2 content and lipid peroxidation were investigated and the activities of antioxidant enzymes [superoxide ... -
The role of p-coumaric acid on physiological and biochemical response of chia seedling under salt stress
(University of the Western Cape, 2020)The role of phenolic acids in mitigating salt stress tolerance have been well documented. However, there are contradicting reports on the effect of exogenously applied phenolic acids on the growth and development of various ... -
Signalling molecule “calcium” improves germination and growth of Sorghum bicolor seedlings under salt stress
(University of the Western Cape, 2021)Abiotic stress, mainly in the form of extreme temperatures, drought and salinity has caused major crop losses worldwide, putting a severe strain on agriculture. Salinity severely limits plant growth and productivity and ...