Browsing Department of Medical BioSciences by Issue Date
Now showing items 21-40 of 230
-
The effects of PGA2 on cell cycle progression in oesophageal carcinoma cells
(University of the Western Cape, 2003)The molecular mechanisms causing anti-mitotic and cytotoxic effects of prostaglandin .A2 [PGA2 (CzoHroOa)] treatment of human oesophageal carcinoma (WHCO3) cells were investigated. WHCO3 cells, incubated with cytotoxic ... -
The effects of Elytropappus rhinocerotis Cass and Pelargonium triste (L.) L'Hèrit on animal health and metabolism
(University of the Western Cape, 2003)Many South Africans use cultural traditions and practices in the management of their health. Elytropappus rhinocerotis is an important medicinal plant, which is widely distributed in regions of South Africa. The objective ... -
An electrophysiological exploration into the Sertoli cell, utilizing plant extracts with a view to contraception
(University of the western cape, 2003)Certa in medicinal plant extracts have been shown to have a contraceptive effect on male rats (Rajasekaran et al. , 1988) and mice (Kong et al., 1986). A possible site for the mechanism of action has been identified as the ... -
Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis
(University of the Western Cape, 2005)This thesis consists of a brief description on cancer, carcinogenesis, the changes in the type and level of dietary fat available in our diets over time and association with the development of certain diseases. The main ... -
Apoptotic markers in ejaculated human spermatozoa
(University of the Western Cape, 2005)The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation ... -
The Prevalence of Members of the “Red Complex” in Pregnant Women as Revealed by PCR and BANA Hydrolysis.
(University of the Western Cape, 2005)Increased levels of oestrogen and progesterone during pregnancy may lead to periodontal disease. The anaerobic Gram-negative bacteria called red complex (Porphyromonas gingivalis, Tannerella forsythensis and Treponema ... -
The influence of maternal nicotine exposure on selected glycolytic and cytochrome P450 enzymes in developing neonatal rat lung
(University of the Western Cape, 2005)The structural and functional integrity of a developing and maturing fetal and neonatal lung is critically dependent on carbohydrate metabolism. The energy derived from carbohydrate metabolism is utilized during the processed ... -
Synthesis and applications of functionalized pyridinyl imine complexes of palladium
(University of the Western Cape, 2005)The synthesis and characterization of pyridinyl α-diimine Pd(II) complexes having a functionalized hydrocarbon attached to the imino nitrogen was performed. The catalytic activity of these complexes were then evaluated in ... -
An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development
(University of the Western Cape, 2006)In the 20th century, where tobacco smoking continues to be the leading preventable cause of death, an alarming number of people continue to smoke, despite awareness of the implications of exposure for themselves and those ... -
The effect of gonadotropin-releasing hormones (GnRH) I & II on sperm motility and acrosome status of the Vervet monkey (Chlorocebus aethiops) in vitro
(University of the Western Cape, 2006)Gonadotropin Releasing Hormone (GnRH) is a hypothalmic decapeptide, which regulates mammalian gonadotropin secretions by binding to specific, high affinity receptors in the pituitary. Two forms of GnRH (GnRH I and GnRH II) ... -
Using internet-enabled remote instrumentation for research and training in physics: evaluation of different diffusion barriers for silver metallization
(2007)The growth of the Internet has led to many interesting developments for both educational and commercial purposes. In this project an attempt was made to use the Internet for a research purpose to facilitate the determination ... -
The antihypertentive effect of aqueous extract O Africana leaves
(University of the Western Cape, 2007)The incidence of cardiovascular diseases, including hypertension, is on the increase worldwide. Medicinal plants played an important role in the treatment of hypertension for centuries. Very few scientific studies have, ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ... -
Synergistic effects of mixtures of fungicides and medicinal plant extracts against Botrytis cinerea
(University of the Western Cape, 2008)We hypothesize that South African medicinal plants contain compounds that can act in synergism with synthetic antifungal compounds. Four fungicides - Sporekill™, Rovral™, Terminator™ and Teldor™ at doses 0.1, 0.2, 0.4 and ... -
Synergistic effects of mixtures of fungicides and medicinal plant extracts against Botrytis cinerea
(University of the Western Cape, 2008)We hypothesize that South African medicinal plants contain compounds that can act in synergism with synthetic antifungal compounds. Four fungicides - Sporekill™, Rovral™, Terminator™ and Teldor™ at doses 0.1, 0.2, 0.4 and ... -
The development and implementation of biomarker assays for estrogenic endocrine disruptors
(University of the Western Cape, 2008)Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances ... -
Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
(University of the Western Cape, 2008)Respiratory tract infections are one of the leading causes of morbidity and mortality across the world. This is especially true for infants, young children, the elderly and the immunocompromised. The strain placed on ... -
Organisational commitment after a transformation process at a provincial government department
(University of the Western Cape, 2008)Organisations are by nature, dynamic entities that continuously undergo transformation in response to both internal and external pressures, which are imposed on them (Robbins, Odendaal & Roodt, 2003). Government departments ... -
The use of in vitro assays to screen for endocrine modulation
(University of the Western Cape, 2008)Aspalathus linearis (A. linearis), commonly known as Rooibos tea or Red bush tea and Camellia sinensis (C. sinensis) or Black tea are beverages that are consumed throughout the world. These teas possess antioxidant, ... -
Aspects of the interrelation between hypertension and insulin resistance: a preliminary study
(2009)Background: It is well known that some genetic factors and dietary factors, such as excessive salt intake and excessive caloric intake (resulting in obesity) are risk factors for hypertension. Fifty percent of all ...