Browsing Magister Scientiae - MSc (Medical BioSciences) by Title
Now showing items 67-86 of 160
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line
(University of the Western Cape, 2014)This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. ... -
The efficiency of drinking water treatment plants in removing immunotoxins
(University of the Western Cape, 2010)The aim of this study was to evaluate the effectiveness of water treatment processes of two drinking water plants to remove immunotoxins and steroid hormones. Raw and treated drinking water was screened for effects on ... -
An electrophysiological exploration into the Sertoli cell, utilizing plant extracts with a view to contraception
(University of the western cape, 2003)Certa in medicinal plant extracts have been shown to have a contraceptive effect on male rats (Rajasekaran et al. , 1988) and mice (Kong et al., 1986). A possible site for the mechanism of action has been identified as the ... -
Epidemiological study of Tuberculosis in Macassar camp
(University of the Western Cape, 1995)The aim of this study was to determine and evaluate the prevalence of TB infection, active TB cases and the risk factors associated with TB infection in Macassar Camp in Macassar (about 40 km from Cape Town on the False ... -
Evaluating cape honey bee sperm quality and the in vitro effect of miticides on sperm functionality and structure
(University of Western Cape, 2021)Apis mellifera (honey bees) are essential pollinators and thus considered a keystone species. Reproductive success is therefore important to the survival of the species, with drone sperm quality playing a vital role in ... -
Evaluating the neuroprotective effects of fermented rooibos herbal tea in Wistar rats exposed to bisphenol-A during gestation and lactation
(University of the Western Cape, 2019)Exposure to endocrine-disrupting chemicals as bisphenol A (BPA) during gestation and early postnatal life is known to disrupt normal developmental processes and alter the body’s endocrine system leading to deleterious ... -
Evaluation of standard and development of new sperm function tests in selected primate species
(University of the Western Cape, 2017)Male infertility in humans has increased in the last few decades and could be as high as 40%, while up to 50% of these men have ''unexplained'' (idiopathic) infertility. Although newly developed molecular techniques have ... -
Evaluation of sperm functionality in non-human primates, focussing on sperm capacitation
(University of the Western Cape, 2019)The incidence of male infertility is increasing, with up to 50% of infertile males having “unexplained” (idiopathic) infertility. Newly developed molecular techniques have great value in detecting subtle causes of male ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There are a number of pesticides that are suspected to be endocrine disrupters Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Hetichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
An evaluation of the biopesticidal characteristics of Hetichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
Examination of the biocompatibility and anti-microbial activity of coated dental implants
(University of the Western Cape, 2017)Teeth are important to all people for chewing, speech and aesthetics. Tooth decay, periodontal disease and physical trauma or injuries are the main causes of tooth loss. There are different forms of treatment for tooth ... -
Expression of human coronavirus NL63 and SARS-CoV nucleocapsid proteins for antibody production
(University of the Western Cape, 2012)Human Coronaviruses (HCoVs) are found within the family Coronaviridae (genus, Coronavirus) and are enveloped, single-stranded, positive-sense RNA viruses. Infections of humans by coronaviruses are not normally associated ... -
Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ... -
Gene expression of xenobiotic metabolising enzymes in rat liver and kidney: differential effects of rooibos and honeybush herbal teas
(2011)Laboratory studies, epidemiological investigations and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and therapy. Flavonoids may interfere in several steps that lead to ... -
Hyperactivation in human semen and sperm subpopulations by selected calcium modulators
(University of the Western Cape, 2014)A functional sperm is critical for successful fertilization in order to deliver an intact genome to the site of fertilization. It is often characterized by high motility and normal morphology. Moreover, sperm hyperactivated ... -
Identification and validation of putative therapeutic and diagnostic antimicrobial peptides against HIV: An in silico approach
(University of the Western Cape, 2013)Background: Despite the effort of scientific research on HIV therapies and to reduce the rate of HIV infection, AIDS remains one of the major causes of death in the world and mostly in sub-Saharan Africa. To date, neither ... -
The identification of novel biomarkers in response to pollutant exposure using proteome profiler arrays
(University of Western Cape, 2020)Nanotechnology is a rapidly expanding field with a multitude of practical uses namely textiles, cosmetics, agriculture, and health sciences. The focus, for the purposes of this thesis, will be on carbon dots. The small ... -
Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
(University of the Western Cape, 2012)Athymic nude mouse models have been extensively used to study biological behaviour of normal and diseased human tissues. In such models, immune-deficient mice act as hosts for cysts constructed from human material. A unique ...