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Now showing items 71-77 of 77
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)
Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to
tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline
drug for decades. However, several ...
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)
Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during
infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and
about 15% of all paediatric mortalities. ...
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
(University of the Western Cape, 2018)
Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ...
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
(University of the Western Cape, 2018)
Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic
sources is potentially deleterious to the developing nervous system resulting in oxidative stress,
structural damage, altered ...
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
(University of the Western Cape, 2017)
Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense
RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004,
human coronavirus NL63 (HCoV-NL63) was discovered by ...
The effect of rooibos and green tea flavnoids on the physiology of TM3 Leydig cells
(University of the Western Cape, 2018)
Camellia sinensis (C.sinesis) and Aspalathus linearis (A.linearis) are popular beverages consumed in many countries. Consumption of these plants may protect against cardiovascular disease, neurodegenerative disease, various ...
Comparison between chemical and tissue culture methods to monitor environmental Estrogens
(University of the Western Cape, 2012)
Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals in the environment that interfere with the synthesis, secretion, distribution and function or elimination of natural hormones in the body. Environmental ...