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Now showing items 51-60 of 108
Discovery of cytotoxic natural products from South African marine sponges
(University of the Western Cape, 2018)
Cancer is a major health problem worldwide and killing millions of people each year. The use
of natural products as chemotherapeutic agents is well established, however, many of the
currently available drugs are associated ...
An investigation into the competency framework required for the responsible pharmacist in the pharmaceutical manufacturing sector in South Africa
(The University of the Western Cape, 2017)
The pharmaceutical manufacturing sector operates within a highly regulated
environment, with companies accountable to South African statutory bodies. The
responsible pharmacist (RP) is responsible for their company’s ...
Polymer Coating of an Optimized Nano Lipid Carrier System of Harpagophytum Procumbens Extract for Oral Delivery
(University of the Western Cape, 2017)
Harpagophytum procumbens is a traditional medicinal plant widely used in South African
traditional healthcare to treat a range of ailments like degenerative rheumatoid arthritis,
osteoarthritis, tendonitis, kidney inflammation, ...
Review of the effectiveness of the medicines regulatory systems in Zambia over the period 1995 to 2015
(University of the Western Cape, 2018)
Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study
was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory-
frameworks ...
Evaluation of the anticonvulsant activity of Elytropappus rhinocerotis (L.f) Less
(University of the Western Cape, 2016)
M.Pharm thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western
Cape. Epilepsy is a worldwide neurological disorder which is also prevalent in South Africa. Herbal
medicines, besides orthodox ...
The use of complementary and alternative medicines in the treatment of menopausal symptoms by private healthcare patients in Pretoria, South Africa
(University of the Western Cape, 2017)
BACKGROUND
The use of complementary and alternative medicine (CAM) is widespread in the treatment of
menopausal symptoms. While observational studies indicate that CAMs can bring some relief
of symptoms, there is mixed ...
Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
(University of the Western Cape, 2018)
The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ...
Formulation and evaluation of polymeric micelles for improved oral delivery of tenofovir disoproxil fumarate and zidovudine using poly-lactic-co-glycolic acid nanoparticles
(University of the Western Cape, 2018)
Background: Tenofovir disoproxil fumarate (TDF) and Zidovudine (AZT) are both nucleotide and nucleoside analogue reverse transcriptase inhibitors (NtRTIs and NRTIs), respectively. They are used for the management and ...
Cost-Effectiveness of selecting an Enantiopure formulation over a racemic mixture
(University of the Western Cape, 2017)
The aim of this study is to provide more information in terms of the cost-effectiveness of
selecting an enantiopure formulation over a racemic mixture in the context of promoting rational
use of medicines. This was done ...
Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
(University of the Western Cape, 2018)
Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ...