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Now showing items 61-70 of 78
Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)
Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ...
Evaluation of sperm functionality in non-human primates, focussing on sperm capacitation
(University of the Western Cape, 2019)
The incidence of male infertility is increasing, with up to 50% of infertile males having “unexplained” (idiopathic) infertility. Newly developed molecular techniques have great value in detecting subtle causes of male ...
The efficiency of drinking water treatment plants in removing immunotoxins
(University of the Western Cape, 2010)
The aim of this study was to evaluate the effectiveness of water treatment processes of two drinking water plants to remove immunotoxins and steroid hormones. Raw and treated drinking water was screened for effects on ...
Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW 264.7
(University of the Western Cape, 2019)
Graphene oxide (GO) is a single carbon layer, oxygen bearing graphene derivative, containing hydroxyl and carboxyl groups. Graphene oxide nanoparticles (GONPs) are promising nanomaterials for a variety of applications such ...
Brine shrimp lethality test and acetylcholine esterase inhibition studies on selected South African medicinal plants
(University of the Western Cape, 2012)
Research into traditional medicines is often conducted in a multidisciplinary approach as motivated by a desire to understand them in as complete a manner as possible,realizing their chemistry, biology and pharmacology. ...
The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)
Brain endothelial cell types are frequently used as in vitro models to study the
blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times
to cause BBB dysfunction which is crucial to the initiation ...
Cloning and expression of human cyclophilin A and its interaction with human coronavirus NL63 nucleocapsid protein
(University of the Western Cape, 2011)
Coronaviridae family is composed of a number of ribonucleic acid (RNA)-containing viruses currently classified into two genera, the coronavirus and torovirus. The family is classified together with the Arteviridae in the ...
Molecular genetics: strategies to identify congenital cataract genes in captive-bred Vervet monkeys
(University of the Western Cape, 2012)
The present study describes molecular aspects of inherited congenital cataract in captive-bred Vervet monkeys. Congenital cataracts are lens opacities that are present at birth or soon after birth and include hereditary ...
Identification and validation of putative therapeutic and diagnostic antimicrobial peptides against HIV: An in silico approach
(University of the Western Cape, 2013)
Background: Despite the effort of scientific research on HIV therapies and to reduce the rate
of HIV infection, AIDS remains one of the major causes of death in the world and mostly
in sub-Saharan Africa. To date, neither ...
Comparison between chemical and tissue culture methods to monitor environmental Estrogens
(University of the Western Cape, 2012)
Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals in the environment that interfere with the synthesis, secretion, distribution and function or elimination of natural hormones in the body. Environmental ...