Browsing Magister Pharmaceuticae - MPharm by Issue Date
Now showing items 101-120 of 141
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Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Microbiological parameters that influence the treatment outcomes of monodrug and multidrug-resistant tuberculosis
(University of the Western Cape, 2017)Previous studies have reported microbiological parameters such as HIV infection, resistance to anti-TB drugs such as fluoroquinolones, resistance to previous treatment with anti-TB drugsand extrapulmonary TB, causing poor ... -
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
(University of the Western Cape, 2018)The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ... -
Discovery of cytotoxic natural products from South African marine sponges
(University of the Western Cape, 2018)Cancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established, however, many of the currently available drugs are associated ... -
Formulation and evaluation of polymeric micelles for improved oral delivery of tenofovir disoproxil fumarate and zidovudine using poly-lactic-co-glycolic acid nanoparticles
(University of the Western Cape, 2018)Background: Tenofovir disoproxil fumarate (TDF) and Zidovudine (AZT) are both nucleotide and nucleoside analogue reverse transcriptase inhibitors (NtRTIs and NRTIs), respectively. They are used for the management and ... -
Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
(University of the Western Cape, 2018)Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ... -
Antimicrobial discovery from South African marine algae
(University of the Western Cape., 2018)Antimicrobials are chemical compounds that destroy or inhibit the growth of microorganisms. The majority of these antimicrobials are actually natural products or natural product derived with key examples being the pioneer ... -
Service learning in pharmacy: Evaluation of tuberculosis screening by pharmacy students in primary health care facilities.
(University of the Western Cape, 2019)Background: Tuberculosis (TB) is one of the arms of the so-called quadruple burden of disease in South Africa. One of the major impediments to TB control is failure to detect the disease, and undiagnosed cases in the ... -
Bioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatum
(University of the Western Cape, 2019)Due to the contribution of hypertension to various cardiovascular diseases, many studies are currently focused on identifying efficient bioactive compounds with antihypertensive activity and thus reducing the levels of ... -
Disposal of unused medicines from households in Cape Town
(University of Western Cape, 2019)Evidence indicates that most South African households do not dispose of unused medicines in the manner prescribed by the medicine’s regulatory authority. This trend is not unique to South Africa, but several developing ... -
Isolation and Bioassay evaluation of Angiotensin Converting Enzyme inhibitory compounds of Centella asiatica
(University of the Western Cape, 2019)Hypertension is by far the most common risk factor for cardiovascular disease (CVD), which has been identified as the leading cause of death worldwide and a major economic burden in developing countries. Over the years, ... -
Medicine therapy management for diabetic club Patients at a primary health care clinic: exploring a Potential role for pharmacists
(University of the Western Cape, 2019)Diabetes mellitus is a complex chronic condition and has become a major public health concern worldwide. Many diabetic patients are accessing primary health care (PHC) clinics for diabetes care. Diabetic patients who are ... -
Phytochemical and biological studies of Helichrysum cymosum
(University of the Western Cape, 2020)Diabetes mellitus (DM) is well known as a group of systemic metabolic disorders with a considerable mortality rate around the world. Hyperglycemia is the main consequence of DM, which results from the shortage in insulin ... -
Cheminformatic Approaches to Hit-Prioritization and Target Prediction of Potential Anti-MRSA Natural Products
(University of the Western Cape, 2020)The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ... -
Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products
(University of Western Cape, 2020)The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ... -
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of the Western Cape, 2020)Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited ... -
Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
(University of the Western Cape, 2020)Neurodegenerative diseases (ND) are chronic and progressive in nature, and characterized by the gradual loss of neurons in various regions of the central nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's ... -
The formulation and characterisation of corticosteroid loaded Ethosomes for topical delivery
(University of the Western Cape, 2020)Background/Introduction: Atopic dermatitis (AD) is one of the most prevalent diseases worldwide. It is a rapidly growing field of study with several research avenues to explore its pathophysiology and to find innovative ... -
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of Western Cape, 2020)Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited ...