Browsing Magister Pharmaceuticae - MPharm by Title
Now showing items 107-126 of 141
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Pharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Krauss
(University of the Western Cape, 2011)Syzygium cordatum is a medicinal plant indigenous to South Africa and Mozambique, commonly used to treat stomach aches, diabetes, respiratory problems and tuberculosis. In spite of the folklore use, adequate scientific ... -
Pharmacological evaluation of some central nervous system effects of Cotyledon Orbiculata
(University of the Western Cape, 2005)The use of traditional medicine through the use of medicinal plants in Africa and especially in South Africa has long been considered an important characteristic of people's daily lives and socio-cultural heritage. Cotyledon ... -
Pharmacological evaluation of the medicinal plants, pelargonium triste (l), elytropappus rhinocerotis (l.f), and olea europaea africana (mill.) for antidiarrhoeal activity in mice
(University of the Western Cape, 2001)Three medicinal plant species, Pelargonium triste (L.), Elytropappus rhinocerof,s (L.F.), and Olea europaea africana (Mill.), commonly used in the Western Cape traditional medicine to treat various ailments were assessed ... -
Pharmacovigilance: the responsibility of pharmaceutical companies to protect patients from drug-related harms
(University of the Western Cape, 2014)Healthcare professionals (HCPs) have a primary role to play in the detection, assessment and spontaneous reporting of adverse drug reactions (ADRs). An improvement of their related knowledge, attitude and practice concerning ... -
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment regimen. From a literature study it became ... -
Phytochemical and biological studies of Helichrysum cymosum
(University of the Western Cape, 2020)Diabetes mellitus (DM) is well known as a group of systemic metabolic disorders with a considerable mortality rate around the world. Hyperglycemia is the main consequence of DM, which results from the shortage in insulin ... -
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ... -
Polymer Coating of an Optimized Nano Lipid Carrier System of Harpagophytum Procumbens Extract for Oral Delivery
(University of the Western Cape, 2017)Harpagophytum procumbens is a traditional medicinal plant widely used in South African traditional healthcare to treat a range of ailments like degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, ... -
Preparation, characterisation and evaluation of Artemisia afra phytosomes with modified release properties
(University of the Western Cape, 2017)Dissolution studies on various dosage forms (powder, tablets, teabags and alginate beads) of the Artemisia afra freeze dried aqueous extract (FDAE) all exhibit a rapid release profile. Generally, such a release profile may ... -
Prescribing practice at a tertiary level paediatric hospital in South Africa
(University of the Western Cape, 2014)The objectives of the present study were to describe the type and frequency of prescribing errors and error frequency, to determine the error frequency for different drug classes, to identify potential drug interactions ... -
A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry
(University of the Western cape, 2016)The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals ... -
Quality of the combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) in the private retail pharmacies of Nyeri Town, Kenya. Results from a postmarket quality study
(University of the Western Cape, 2015)Background: The effectiveness of the combined oral contraceptive pill as a family planning method is dependent on its quality. The quality of medicines on the healthcare market is established through postmarket quality ... -
Rational drug therapy monitoring in type 2 diabetes mellitus : using glycated haemoglobin as a guide for change in therapy
(University of the Western Cape, 2015)Type 2 diabetes mellitus is a progressive disease characterised by defects in insulin secretion, insulin action or both. Proper management of diabetes with appropriate drug and lifestyle interventions, guided by proper ... -
Retrospective descriptive evaluation of empiric carbapenem-sparing regimens versus carbapenem use in non-intensive care patients at a district hospital in South Africa
(University of Western Cape, 2021)Antimicrobial resistance is a global concern associated with increased morbidity and mortality. It has been estimated that, by 2050, the continuous escalation of antimicrobial resistance, globally, will result in more ... -
Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
(University of Western Cape, 2021)In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes are described ranging from 12 to 18 months, these ... -
Service learning in pharmacy: Evaluation of tuberculosis screening by pharmacy students in primary health care facilities.
(University of the Western Cape, 2019)Background: Tuberculosis (TB) is one of the arms of the so-called quadruple burden of disease in South Africa. One of the major impediments to TB control is failure to detect the disease, and undiagnosed cases in the ... -
South African patent law : developing a balance between the rights of the patients and promoting innovation within the pharmaceutical industry
(University of the Western Cape, 2015)Background: In South Africa many patented medicines are either unavailable or carry prices that most patients cannot afford. The effects of the patents systems on patient access could greatly depending on how the burden ... -
Stability of freeze-dried aqueous and other modified extracts of Leonotis leonurus
(University of the Western Cape, 2017)Leonotis leonurus, a South African indigenous medicinal plant, is frequently used in the form of a tea. However, this dosage form has many disadvantages. Consequently three L. leonurus solid extract preparations were ... -
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
(University of the Western Cape, 2021)Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ... -
A supramolecular derivatised study of BIS(Adamantan-1- Aminium) carbonate
(University of the Western Cape, 2014)In this study, new solid supramolecular derivatised forms of bis(adamantine-1-aminium) carbonate (ADTCO3) were prepared. ADTCO3 is a derivative of amantadine used for Parkinson’s disease and has antiviral properties against ...