Browsing Magister Pharmaceuticae - MPharm by Issue Date
Now showing items 81-100 of 141
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Hybrid molecules as inhibitors of the monoamine oxidases and caspase 3 for neurodegenerative disorders
(University of the Western Cape, 2016)Neurodegenerative diseases are multifactorial in nature, and taking the complex nature of these disorders into consideration, multi-target directed ligands may present as better options to treat these disorders than the ... -
Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability
(University of the Western Cape, 2016)Background: Zidovudine (AZT) is a very useful drug for the management of Human Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. ... -
A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry
(University of the Western cape, 2016)The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals ... -
Investigation of the antidiabetic activity of Cnicusbenedictus L. in rats
(University of the Western Cape, 2016)Diabetes Mellitus, one of the major diseases affecting human population all over the world has caused significant morbidity and mortality. The management of this condition has raised the demand of safe and cost effective ... -
Evaluation of the anticonvulsant activity of Elytropappus rhinocerotis (L.f) Less
(University of the Western Cape, 2016)M.Pharm thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western Cape. Epilepsy is a worldwide neurological disorder which is also prevalent in South Africa. Herbal medicines, besides orthodox ... -
Formulation of a nevirapine co-crystal as a liquid dosage form
(University of the Western Cape, 2016)Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of ... -
Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease
(University of the Western Cape, 2016)Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language ... -
Tacrine, trolox and tryptoline as lead compounds for the design and synthesis of multi-target drugs for Alzheimer's disease therapy
(University of the Western Cape, 2016)The cascade of neurotoxic events involved in the pathogenesis of Alzheimer's disease may explain the inefficacy of currently available treatment based on acetylcholinesterase inhibitors (AChEI - donepezil, galantamine, ... -
Stability of freeze-dried aqueous and other modified extracts of Leonotis leonurus
(University of the Western Cape, 2017)Leonotis leonurus, a South African indigenous medicinal plant, is frequently used in the form of a tea. However, this dosage form has many disadvantages. Consequently three L. leonurus solid extract preparations were ... -
Paving a way to effectively regulate African traditional medicines in South Africa
(University of the Western Cape, 2017)BACKGROUND: Following the historical suppression of traditional medicines in South Africa, the government published their National Health Plan in 1994 which made provision for traditional healing as an integral and ... -
Traditional, complementary and alternative medicine in Botswana: patients’ attitudes, knowledge and use
(University of the Western Cape, 2017)BACKGROUND: The purpose of this study was to determine use, knowledge and attitudes towards traditional, complementary and alternative medicine (TCAM) in Botswana among people who visit public health facilities. PRIMARY ... -
Design, Synthesis and Evaluation of Indole Derivatives as Multifunctional Agents against Alzheimer's disease.
(University of the Western Cape, 2017)Alzheimer's disease (AD) is an age related neurodegenerative disorder characterised by progressive memory loss and cognitive impairment. It is one of several neurodegenerative disorders occurring as a result of a process ... -
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ... -
Analysis on access to antiretroviral therapy for patients with different income and educational level, and the effect of treatment on quality of life after two to three months of therapy
(University of the Western cape, 2017)Access to antiretroviral therapy (ART) for HIV positive patients has brought hope and a chance to a healthier longer life with improved quality of life (QoL). In this study we explored the difference in health related ... -
Polymer Coating of an Optimized Nano Lipid Carrier System of Harpagophytum Procumbens Extract for Oral Delivery
(University of the Western Cape, 2017)Harpagophytum procumbens is a traditional medicinal plant widely used in South African traditional healthcare to treat a range of ailments like degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, ... -
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs in tuberculosis patients. However, currently in South Africa, no studies have been done on ethionamide (ETH) PK in adult MDR-TB patients ... -
Preparation, characterisation and evaluation of Artemisia afra phytosomes with modified release properties
(University of the Western Cape, 2017)Dissolution studies on various dosage forms (powder, tablets, teabags and alginate beads) of the Artemisia afra freeze dried aqueous extract (FDAE) all exhibit a rapid release profile. Generally, such a release profile may ... -
Development of a model to predict the cost of treatment of breast cancer with chemotherapy at Groote Schuur hospital
(University of the Western Cape, 2017)In South Africa, breast cancer dominates other forms of cancer affecting women in both prevalence and mortality rates according to the National Cancer Registry. The incidence and cost of breast cancer have been on the rise ... -
Integrating Complementary and Alternative Medicines into Pharmacy Practice: Identifying challenges in meeting professional responsibilities and training needs
(University of the Western Cape, 2017)Community pharmacies are popular suppliers of complementary and alternative medicines (CAMs) and pharmacists encounter requests from consumers for information on them. The purpose of this study was to assess the extent to ... -
A Community Pharmacy perspective on the epidemiology of antimicrobial drugs in the Kuilsriver urban area
(University of the Western Cape, 2017)The epidemiology of drugs is 'defined as the manner in which drugs are used by doctors, nurses, pharmacists and patients. As such epidemiology of antimicrobial drugs is the manner in which this class of drugs is used by ...