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Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
(University of Western Cape, 2021)
In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua,
Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes
are described ranging from 12 to 18 months, these ...
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)
Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South
Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment
regimen. From a literature study it became ...
Taste-masking of efavirenz through microencapsulation
(University of the Western Cape, 2021)
It is a well-known fact that a significant gap exists in the development of child-friendly
dosage forms, detrimentally affecting paediatric patient compliance, especially in the treatment of
debilitating diseases such ...
Venous thromboembolism risk assessment and prophylaxis in selected public sector hospitals in the Cape Town metropole
(University of the Western Cape, 2021)
Background: Venous thromboembolism (VTE) is reported to be the leading
cause of death in hospitalised patients worldwide. Thromboprophylaxis
provides a well-established and evidence-based approach to preventing VTE.
This ...
An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin
(University of Western Cape, 2021)
Malaria remains one of the top mortality causes in the sub-Saharan African region, especially
among pregnant women and infants. Despite several measures being implemented within the
affected areas such as the use of ...
Retrospective descriptive evaluation of empiric carbapenem-sparing regimens versus carbapenem use in non-intensive care patients at a district hospital in South Africa
(University of Western Cape, 2021)
Antimicrobial resistance is a global concern associated with increased morbidity and mortality. It has been estimated that, by 2050, the continuous escalation of antimicrobial resistance, globally, will result in more ...
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
(University of the Western Cape, 2021)
Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ...
Current practices of urinary tract infection management: An observational study at primary healthcare level
(University of Western Cape, 2021)
Antibiotic resistance (ABR) is a global healthcare burden complicating the treatment of various infections. The infectious diseases burden is heavy in primary care. Urinary tract infections (UTIs) are common outpatient ...