| dc.contributor.advisor | Mugabo, Pierre | |
| dc.contributor.author | Ezeukwu, Ifeoma Patricia | |
| dc.date.accessioned | 2018-08-02T12:27:41Z | |
| dc.date.available | 2018-08-02T12:27:41Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | http://hdl.handle.net/11394/6186 | |
| dc.description | Magister Pharmaceuticae - Mpharm | en_US |
| dc.description.abstract | Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients that are infected with HIV
and those without HIV infection. Therefore, the objective of this current study was
firstly, to find out ethionamide plasma concentration using the LC-MS method;
secondly, to evaluate and compare the pharmacokinetics of ethionamide in MDR-TB
patients infected with and without HIV infection; thirdly, to examine the effects of
ARVs and kidney impairment on the PK of ethionamide and fourthly, to find out the
consequence of sex and age on ETH PK parameters. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.subject | Multidrug-resistant tuberculosis | en_US |
| dc.subject | Human immunodeficiency virus | en_US |
| dc.subject | Mycobacterium tuberculosis | en_US |
| dc.subject | Antiretroviral agents | en_US |
| dc.subject | Ethionamide | en_US |
| dc.subject | Pharmacokinetics | en_US |
| dc.subject | Plasma concentrations | en_US |
| dc.subject | Liquid chromatography | en_US |
| dc.subject | Mass spectrometry | en_US |
| dc.title | Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection | en_US |
| dc.type | Thesis | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
