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Development of an operon detection algorithm to analyze gene regulation in drug resistant Mycobacterium tuberculosis
(University of the Western Cape, 2022)
In prokaryotes, operon structures often form to allow microorganisms to respond rapidly and efficiently to changing environmental conditions. Operons are sets of neighbouring genes which are co-regulated and co-transcribed. ...
A bioinfonnatics approach to the study of the transcriptional regulation of AMPA Glutamate receptors (GRIAs) and genes whose expression are co-regulated with GRIAs
(University of the Western Cape, 2009)
It was postulated that each gene has three main sets of transcriptional elements: one which is gene-specific, one which is family-specific, and a third which is tissue-specific. The starting hypothesis for this project had ...
Novel genomic biomarkers for pediatric and adult acute myeloid leukemia
(University of the Western Cape, 2023)
Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that affects individuals of all ages. AML patients are categorized into favorable, intermediate, and adverse risks based on patients' genomic features ...
Development and implementation of ontology-based systems for mammalian gene expression profiling
(University of the Western Cape, 2009)
The use of ontologies in the mapping of gene expression events provides an
effective and comparable method to determine the expression profile of an entire
genome across a large collection of experiments derived from ...