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Now showing items 11-20 of 38
A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)
This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ...
The molecular evolution and epidemiology of Rubella virus
(University of the Western Cape, 2014)
Despite widespread rubella virus (RV) vaccination programs, annually RV still
causes severe congenital defects in an estimated 100,000 children globally. A
concerted attempt to eradicate RV is currently underway and ...
The potential of commercial praziquantel formulations as "off label" treatments for diplectanum oliveri (monogenea) infecting cultured argyrosomus species in the South African marine finfish aquaculture industry
(University of the Western Cape, 2012)
Aquaculture is a vast industry all over the world and has increased significantly
during the past 30 years. In South Africa, finfish aquaculture farms stretch from
Gansbaai to as far as Richards bay with the potential ...
Evolution of HIV-1 subtype C gp120 envelope sequences in the female genital tract and blood plasma during acute and chronic infection
(University of the Western Cape, 2014)
Heterosexual transmission of HIV-1 via the female genital tract is the leading route of HIV infection in sub-Saharan Africa. Viruses then traffic between the cervical compartment and blood ensuring pervasive infection. ...
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)
Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ...
Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
(University of the Western Cape, 2015)
Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ...
Normalization and statistical methods for crossplatform expression array analysis
(University of the Western Cape, 2012)
A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ...
Characterising the Prevalence and Mode of CXCR4 Usage in HIV-1 Group M Subtype C
(University of the Western Cape, 2013)
Determination of CXCR4-usage patterns is essential in establishing suitability
of CCR5 antagonist prescription in HIV-1 infected individuals to
prevent treatment failure. Previous studies have suggested a switch ...
Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)
The discovery of microRNAs (miRNAs) is one of the most exciting scientific
breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ...
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(2011)
To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ...