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Now showing items 31-38 of 38
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)
Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ...
Exploring the role of the “glycan-shield” of human immunodeficiency virus in susceptibility to, and escape from, broadly neutralising antibodies
(University of the Western Cape, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune
response and a critical vaccine candidate. However, Env is densely glycosylated and
thereby substantially protected from neutralisation. ...
Development of a data processing toolkit for the analysis of next-generation sequencing data generated using the primer ID approach
(University of the Western Cape, 2018)
Sequencing an HIV quasispecies with next generation sequencing technologies yields a dataset with
significant amplification bias and errors resulting from both the PCR and sequencing steps. Both the
amplification bias ...
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
(University of the Western Cape, 2016)
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease
characterized by the production of a wide range of autoantibodies directed against selfantigens.
SLE can influence almost any organ system and ...
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
(University of the Western Cape, 2018)
Biobanks are collections of biological samples and associated data for future use. The day to
day activities in a biobank laboratory is underpinned by a laboratory information management
system (LIMS). For example, the ...
Regulatory attributes of the carotenoid biosynthetic pathway in Arabidopsis Thaliana under abiotic stress
(University of the Western Cape, 2012)
Carotenoids are tetraprenoid (C40) molecules synthesized in plants, fungi, bacteria and algae, via the carotenoid biosynthetic pathway (CBP). Some carotenoids are readily converted to vitamin A (VA) in humans, e.g. ...
Irradiation induced effects on 6h-SIC
(University of the Western Cape, 2012)
The framework agreement in the year 2000 by the international community to launch Generation IV program with 10 nations, to develop safe and reliable nuclear reactors gave rise to the increased interest in the studies of ...
Management and analysis of HIV -1 ultra-deep sequence data
(University of the Western Cape, 2014)
The continued success of antiretroviral programmes in the treatment of HIV is dependent on access to a cost-effective HIV drug resistance test (HIV-DRT). HIVDRT involves sequencing a fragment of the HIV genome and ...