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Now showing items 21-30 of 44
Computational verification of published human mutations
(University of the Western Cape, 2008)
The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ...
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)
Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ...
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
(University of the Western Cape, 2018)
INTRODUCTION:
Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ...
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
(University of the Western Cape, 2018)
Functional genomics determines the biological functions of genes on a global scale by
using large volumes of data obtained through techniques including next-generation
sequencing (NGS). The application of NGS in biomedical ...
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
(University of the Western Cape, 2019)
The growing size of raw data and the lack of internet communication technology to
keep up with that growth is introducing unique challenges to academic researchers.
This is especially true for those residing in rural ...
Data Science techniques for predicting plant genes involved in secondary metabolites production
(University of the Western Cape, 2018)
Plant genome analysis is currently experiencing a boost due to reduced costs associated with the
development of next generation sequencing technologies. Knowledge on genetic background can be
applied to guide targeted ...
High performance computing and algorithm development: application of dataset development to algorithm parameterization
(University of the Western Cape, 2006)
A number of technologies exist that captures data from biological systems. In addition, several computational tools, which aim to organize the data resulting from these technologies, have been created. The ability of these ...
Molecular modeling and simulation studies to prioritize sequence variants identified by whole-exome sequencing in a South African family with Parkinson's disease
(University of Western Cape, 2021)
Parkinson’s disease (PD) is a neurodegenerative disorder that occurs due to a loss of dopaminergic neurons in the substantia nigra. It is one of the most common neurodegenerative disorders, ranking second only to Alzheimer’s ...
Establishing a framework for an African Genome Archive
(University of Western Cape, 2019)
The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ...
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of the Western Cape, 2021)
The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ...