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Now showing items 31-40 of 44
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of Western Cape, 2021)
The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ...
Investigating the structural effect of Raltegravir resistance associated mutations on the South African HIV-1 Integrase subtype C protein structure
(University of the Western Cape, 2020)
Background and Aims Human Immunodeficiency Virus (HIV) type 1 group M subtype C (HIV-1C) accounts for nearly half of global HIV-1 infections, with South Africa (SA) being one of the countries with the highest infection ...
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of the Western Cape, 2020)
Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ...
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of Western Cape, 2020)
Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ...
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
(University of the Western Cape, 2018)
Biobanks are collections of biological samples and associated data for future use. The day to
day activities in a biobank laboratory is underpinned by a laboratory information management
system (LIMS). For example, the ...
HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations
(University of the Western Cape, 2002)
Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine ...
Reconstruction of gene regulatory networks of inflammation-associated genes in different clinical stages of diffuse large B-cell lymphoma
(University of the Western Cape, 2022)
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy
that is driven by complex gene regulatory networks (GRNs). Numerous genes exert
distinct effects on the progression and therapeutic outcome of DLBCL. ...
A deep learning approach to predicting potential virus species crossover using convolutional neural networks and viral protein sequence patterns
(University of the Western Cape, 2022)
Medical science has made substantial progress toward diagnosing, understanding the pathogenesis, and treating various causative agents of infectious disease; however, novel microbial pathogens continue to emerge, and ...
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
(University of the western cape, 2009)
Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp)
parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and
Nagana in livestock. Research suggests that tsetse fly ...
An investigation into the genetic basis of autosomal recessive Osteogenesis imperfecta (OI) III in a South African family of mixed ancestry
(University of the Western Cape, 2022)
Osteogenesis Imperfecta (OI) is a rare skeletal dysplasia that is primarily characterized by bone fragility, recurrent fractures, and bone deformities. Over the years there has been an increase in the number of genes ...