Department of Biochemistry
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Investigation of socio-demographic, clinical and genetic factors associated with blood pressure and glycaemic control among indigenous South African adult patients
(University of the Western Cape, 2021)Achieving blood pressure and glycaemic treatment targets remain a major public health challenge in individuals with hypertension and diabetes mellitus (DM). This research project was, therefore, designed to investigate the ... -
The effect of kinetin and salt stress on pnp-a expression in erucastrum strigosum and arabidopsis thaliana
(University of the Western Cape, 2002)In agriculture crop productivity is greatly affected by stresses such as salinity, drought, temperature and honnonal changes of crop plants and responses to these stresses. Studies have shown that a natriuretic peptide ... -
Tungsten Telluride Quantum dot-based Biosensor for Alpha-Methylacyl CoA Racemase – An Emerging Prostate Cancer Biomarker
(University of the Western Cape, 2019)Prostate cancer, commonly referred to as adenocarcinoma of the prostate, is the leading cause of cancer death in men in 46 countries, and it was estimated that by the end of 2018 there would approximately be 1.3 million ... -
Electrochemical Aptasensing of B-Type Natriuretic Peptide-A Biomarker for Myocardial Infarction
(University of the Western Cape, 2019)infarction (MI) affects many parts of the western world and in South Africa alone it is estimated that MI is responsible for 1 in 6 deaths (17.3%). Traditional diagnostic methods for MI include an electrocardiograms and ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects.
(University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Bacillus licheniformis isolated from Mozambican soil capable of producing 2, 3-butanediol
(The University of the Western Cpae, 2018)Due to the current fossil fuel sources rapidly depleting as a result of the increased global need, alternative, sustainable and renewable sources are required. Biofuels, which are environmentally friendly, meet all the ... -
Investigation of the intra-cellular localisation of Retinoblastoma Binding Protein 6 using immunofluorescence microscopy
(University of the Western Cape, 2017)Human Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa protein that has been implicated in a number of crucial cellular processes. It forms part of the mRNA 3'-end processing complex in both humans and yeast, and it ... -
Metagenomic analysis and characterization of microbial diversity from hydrothermal samples of El Tatio geyser field, Chile
(University of the Western Cape, 2012)The El Tatio geyser field (ETGF) is the largest known geothermal field in Chile, forming part of a wide spectrum of extremophilic habitats in the country. The ETGF is NaCl rich, with high concentrations of toxic elements ... -
Design and synthesis of polycyclic amine derivatives for sigma receptor activity
(2013)New therapeutic strategies are needed for a diverse array of poorly understood neurological impairments. These include neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, and the psychiatric ... -
Seasonal dynamics of edaphic bacterial communities in the hyper-arid namib desert
(2012)The Namib Desert is a hyper-arid, coastal desert with limited bioavailable water and nutrients; characteristics which collectively impose constraints on edaphic microbial communities. Several studies in the Namib Desert ... -
An in vitro study on the immunotoxicity of sewage effluents discharged into the Eerste River-Kuils river water catchment system
(2008)"The aim of the study was to use in vitro human whole blood cultures to screen the water samples collected from the Eerste/Plankenbrug river system for cytotoxicity and inflammatory activity and for the first time investigate ... -
Genomic instability in South African breast cancer patients
(2013)Breast cancer (BC) is one of the most common malignancies in women. Death results from treatment failure and metastatic disease. Thousands of lives might be saved if it was possible to detect and eliminate occult metastatic ... -
Investigating novel cis-acting regulatory elements involved in the regulation of heat shock response in cardiomyocytes
(2013)Ischemic heart disease is a disease which is characterized by the reduced blood supply to the heart. According to WHO 2013, ischemic heart disease is one of the major causes of death globally. For this reason, it is ... -
Novel genomic approaches for the identification of virulence genes and drug targets in pathogenic bacteria
(University of the Western Cape, 2001)While the many completely sequenced genomes of bacterial pathogens contain all the determinants of the host-pathogen interaction, and also every possible drug target and recombinant vaccine candidate, computational tools ... -
Low detection of exon skipping in mouse genes orthologous to human genes on chromosome 22
(University of the Western Cape, 2002)Alternative RNA splicing is one of the leading mechanisms contributing towards transcript and protein diversity. Several alternative splicing surveys have confirmed the frequent occurrence of exon skipping in human genes. ... -
The development and application of informatics-based systems for the analysis of the human transcriptome
(University of the Western Cape, 2003)Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting evidence for unexpected ... -
Expression and purification of the novel protein domain DWNN
(University of the Western Cape, 2002)Proteins play an important role in cells, as the morphology, function and activities of the cell depend on the proteins they express. The key to understanding how different proteins function lies in an understanding of the ... -
Physical and genetical investigation of the Xp11.3 region on the short arm of the human X-chromosome
(University of the Western Cape, 2004)The pattern of inactivation in the DXS8237E-UBE1-PCTK1 region is of particular interest, since the mechanisms of X chromosome inactivation and the escape from inactivation are, as yet, not fully understood. The inactivation ... -
Optimizing the ion source for polarized protons
(University of the Western Cape, 2005)Beams of polarized protons play an important part in the study of the spin dependence of the nuclear force by measuring the analyzing power in nuclear reactions. The source at iThemba LABS produces a beam of polarized ...
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