Department of Biochemistry
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The adenomatous polyposis coli (APC) and p53 gene status in South African oesophageal cancer patients
(University of the Western Cape, 1996)Oesophageal cancer is the most conmon cause of cancer-related deaths in black males in South Africa. In an effort to understand the molecular nature of oesophageal carcinogenesis in South Africa, two tumour suppressor ... -
Isolation and Partial Characterization Serine Protease Inhibitors from Triticum aestivum cv' Witwol
(University of the Western Cape, 2001)Plant diseases and plant pests are major constraints to plant growth and development, resulting in severe crop losses annually. Plant pathogens can be a variety of things, living and non-living. Non-living pathogens exist ... -
Genetic variation of rana fuscigula in Southern Africa
(University of the Western Cape, 1994)Naturalists have long been engaged in describing and explaining diversity in the biological world. The discovery of the molecular basis of inheritance has led to rapid increase in the use of biological macromolecules in ... -
"Genetic variation between two subspecies of reedfrogs in the genus Hyperolius (Anura: Hyperoliidae)"
(University of the Western Cape, 1993)H. m. broadleyi and H. m. verrucosus are not only different in terms of colour pattern, but distinct genetic differences were detected in restriction site maps of their ribosomal DNA. A sequence divergence value of 13,8% ... -
Identification and partial characterisation of a putative novel plant stress response gene from Arabidopsis thaliana.
(University of the Western Cape, 2000)Exposure of plants to stress results in the expression of plant genes whose products play a role in defence responses against the stress. Stress stimuli to which plants may be exposed are wounding, drought, salinity, ... -
Bioactivity guided fractionation of Sutherlandia frutescens extracts for the induction of apoptosis
(University of the Western Cape, 2003)Sutherlandia frutescens popularly known as "cancer bush" or "kankerbos" is indigenous to South Africa and claimed by traditional healers to have wide therapeutic potential, most specifically against cancer. To verify these ... -
Aberrations in the Retinoblastoma susceptibility gene in tumours from South Africa oesophageal cancer patients
(University of the Western Cape, 1996)Little is known about the genetic events occurring in oesophageal cancer and very few studies have been undertaken to analyse oesophageal tumours from South African patients in this regard. Inactivation of numerous tumour ... -
Genetic variation between two subspecies of Reedfrogs in the genus Hyperolius (Anura: Hyperoliidae)
(University of the Western Cape, 1993)The frog genus Hyperolius is the largest of 19 genera in the Hyperoliidae (Channing, 1939). The members of the genus display considerable morphological homogeneity with a diversity of dorsal colour patterns. The genus is ... -
Investigation of socio-demographic, clinical and genetic factors associated with blood pressure and glycaemic control among indigenous South African adult patients
(University of the Western Cape, 2021)Achieving blood pressure and glycaemic treatment targets remain a major public health challenge in individuals with hypertension and diabetes mellitus (DM). This research project was, therefore, designed to investigate the ... -
The effect of kinetin and salt stress on pnp-a expression in erucastrum strigosum and arabidopsis thaliana
(University of the Western Cape, 2002)In agriculture crop productivity is greatly affected by stresses such as salinity, drought, temperature and honnonal changes of crop plants and responses to these stresses. Studies have shown that a natriuretic peptide ... -
Tungsten Telluride Quantum dot-based Biosensor for Alpha-Methylacyl CoA Racemase – An Emerging Prostate Cancer Biomarker
(University of the Western Cape, 2019)Prostate cancer, commonly referred to as adenocarcinoma of the prostate, is the leading cause of cancer death in men in 46 countries, and it was estimated that by the end of 2018 there would approximately be 1.3 million ... -
Electrochemical Aptasensing of B-Type Natriuretic Peptide-A Biomarker for Myocardial Infarction
(University of the Western Cape, 2019)infarction (MI) affects many parts of the western world and in South Africa alone it is estimated that MI is responsible for 1 in 6 deaths (17.3%). Traditional diagnostic methods for MI include an electrocardiograms and ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects.
(University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Bacillus licheniformis isolated from Mozambican soil capable of producing 2, 3-butanediol
(The University of the Western Cpae, 2018)Due to the current fossil fuel sources rapidly depleting as a result of the increased global need, alternative, sustainable and renewable sources are required. Biofuels, which are environmentally friendly, meet all the ... -
Investigation of the intra-cellular localisation of Retinoblastoma Binding Protein 6 using immunofluorescence microscopy
(University of the Western Cape, 2017)Human Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa protein that has been implicated in a number of crucial cellular processes. It forms part of the mRNA 3'-end processing complex in both humans and yeast, and it ... -
Metagenomic analysis and characterization of microbial diversity from hydrothermal samples of El Tatio geyser field, Chile
(University of the Western Cape, 2012)The El Tatio geyser field (ETGF) is the largest known geothermal field in Chile, forming part of a wide spectrum of extremophilic habitats in the country. The ETGF is NaCl rich, with high concentrations of toxic elements ... -
Design and synthesis of polycyclic amine derivatives for sigma receptor activity
(2013)New therapeutic strategies are needed for a diverse array of poorly understood neurological impairments. These include neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, and the psychiatric ... -
Seasonal dynamics of edaphic bacterial communities in the hyper-arid namib desert
(2012)The Namib Desert is a hyper-arid, coastal desert with limited bioavailable water and nutrients; characteristics which collectively impose constraints on edaphic microbial communities. Several studies in the Namib Desert ... -
An in vitro study on the immunotoxicity of sewage effluents discharged into the Eerste River-Kuils river water catchment system
(2008)"The aim of the study was to use in vitro human whole blood cultures to screen the water samples collected from the Eerste/Plankenbrug river system for cytotoxicity and inflammatory activity and for the first time investigate ... -
Genomic instability in South African breast cancer patients
(2013)Breast cancer (BC) is one of the most common malignancies in women. Death results from treatment failure and metastatic disease. Thousands of lives might be saved if it was possible to detect and eliminate occult metastatic ...
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