Browsing Department of Biochemistry by Title
Now showing items 5-24 of 27
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Design and synthesis of polycyclic amine derivatives for sigma receptor activity
(2013)New therapeutic strategies are needed for a diverse array of poorly understood neurological impairments. These include neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, and the psychiatric ... -
The development and application of informatics-based systems for the analysis of the human transcriptome
(University of the Western Cape, 2003)Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting evidence for unexpected ... -
The effect of kinetin and salt stress on pnp-a expression in erucastrum strigosum and arabidopsis thaliana
(University of the Western Cape, 2002)In agriculture crop productivity is greatly affected by stresses such as salinity, drought, temperature and honnonal changes of crop plants and responses to these stresses. Studies have shown that a natriuretic peptide ... -
Electrochemical Aptasensing of B-Type Natriuretic Peptide-A Biomarker for Myocardial Infarction
(University of the Western Cape, 2019)infarction (MI) affects many parts of the western world and in South Africa alone it is estimated that MI is responsible for 1 in 6 deaths (17.3%). Traditional diagnostic methods for MI include an electrocardiograms and ... -
Expression and purification of the novel protein domain DWNN
(University of the Western Cape, 2002)Proteins play an important role in cells, as the morphology, function and activities of the cell depend on the proteins they express. The key to understanding how different proteins function lies in an understanding of the ... -
Genetic variation between two subspecies of Reedfrogs in the genus Hyperolius (Anura: Hyperoliidae)
(University of the Western Cape, 1993)The frog genus Hyperolius is the largest of 19 genera in the Hyperoliidae (Channing, 1939). The members of the genus display considerable morphological homogeneity with a diversity of dorsal colour patterns. The genus is ... -
"Genetic variation between two subspecies of reedfrogs in the genus Hyperolius (Anura: Hyperoliidae)"
(University of the Western Cape, 1993)H. m. broadleyi and H. m. verrucosus are not only different in terms of colour pattern, but distinct genetic differences were detected in restriction site maps of their ribosomal DNA. A sequence divergence value of 13,8% ... -
Genetic variation of rana fuscigula in Southern Africa
(University of the Western Cape, 1994)Naturalists have long been engaged in describing and explaining diversity in the biological world. The discovery of the molecular basis of inheritance has led to rapid increase in the use of biological macromolecules in ... -
Genomic instability in South African breast cancer patients
(2013)Breast cancer (BC) is one of the most common malignancies in women. Death results from treatment failure and metastatic disease. Thousands of lives might be saved if it was possible to detect and eliminate occult metastatic ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects.
(University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Identification and partial characterisation of a putative novel plant stress response gene from Arabidopsis thaliana.
(University of the Western Cape, 2000)Exposure of plants to stress results in the expression of plant genes whose products play a role in defence responses against the stress. Stress stimuli to which plants may be exposed are wounding, drought, salinity, ... -
An in vitro study on the immunotoxicity of sewage effluents discharged into the Eerste River-Kuils river water catchment system
(2008)"The aim of the study was to use in vitro human whole blood cultures to screen the water samples collected from the Eerste/Plankenbrug river system for cytotoxicity and inflammatory activity and for the first time investigate ... -
Investigating novel cis-acting regulatory elements involved in the regulation of heat shock response in cardiomyocytes
(2013)Ischemic heart disease is a disease which is characterized by the reduced blood supply to the heart. According to WHO 2013, ischemic heart disease is one of the major causes of death globally. For this reason, it is ... -
Investigation of socio-demographic, clinical and genetic factors associated with blood pressure and glycaemic control among indigenous South African adult patients
(University of the Western Cape, 2021)Achieving blood pressure and glycaemic treatment targets remain a major public health challenge in individuals with hypertension and diabetes mellitus (DM). This research project was, therefore, designed to investigate the ... -
Investigation of the intra-cellular localisation of Retinoblastoma Binding Protein 6 using immunofluorescence microscopy
(University of the Western Cape, 2017)Human Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa protein that has been implicated in a number of crucial cellular processes. It forms part of the mRNA 3'-end processing complex in both humans and yeast, and it ... -
Isolation and Partial Characterization Serine Protease Inhibitors from Triticum aestivum cv' Witwol
(University of the Western Cape, 2001)Plant diseases and plant pests are major constraints to plant growth and development, resulting in severe crop losses annually. Plant pathogens can be a variety of things, living and non-living. Non-living pathogens exist ... -
Low detection of exon skipping in mouse genes orthologous to human genes on chromosome 22
(University of the Western Cape, 2002)Alternative RNA splicing is one of the leading mechanisms contributing towards transcript and protein diversity. Several alternative splicing surveys have confirmed the frequent occurrence of exon skipping in human genes. ... -
Metagenomic analysis and characterization of microbial diversity from hydrothermal samples of El Tatio geyser field, Chile
(University of the Western Cape, 2012)The El Tatio geyser field (ETGF) is the largest known geothermal field in Chile, forming part of a wide spectrum of extremophilic habitats in the country. The ETGF is NaCl rich, with high concentrations of toxic elements ... -
Novel genomic approaches for the identification of virulence genes and drug targets in pathogenic bacteria
(University of the Western Cape, 2001)While the many completely sequenced genomes of bacterial pathogens contain all the determinants of the host-pathogen interaction, and also every possible drug target and recombinant vaccine candidate, computational tools ... -
Optimizing the ion source for polarized protons
(University of the Western Cape, 2005)Beams of polarized protons play an important part in the study of the spin dependence of the nuclear force by measuring the analyzing power in nuclear reactions. The source at iThemba LABS produces a beam of polarized ...
