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Now showing items 11-20 of 47
Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products
(University of Western Cape, 2020)
The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ...
Awareness regarding non-steroidal anti-inflammatory drug-related side effects in Johannesburg, South Africa
(University of Western Cape, 2021)
Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly used medications globally, as they are highly effective and easily accessible. The NSAIDs are indicated for mild to moderate pain management. The ...
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of the Western Cape, 2020)
Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke
remain a major cause of death globally. Various deep-rooted factors influence CVD
development; these include but are not limited ...
Change Management in a Biopharmaceutical Company
(University of the Western Cape, 2020)
This study aimed to review the change management implemented in a Biopharmaceutical company in Cape Town in the light of existing literature on change management theory. Three main constructs were identified: process of ...
Selected antiretroviral and anti-tuberculosis drug combinations by non-covalent bonding
(University of Western Cape, 2021)
Treatment of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections have become very complicated due to the advent of drug resistance. Drug combinations offer an alternative approach to reducing the emergence ...
Exploring the factors influencing the sustainability of mobile clinics for the delivery of the expanded programme on immunisation to the rural areas of the Northern Cape.
(University of Western Cape, 2021)
The Northern Cape province has not been able to achieve the 90% immunization target recommended for South Africa’s expanded programme on immunisation (EPI). The situation has been attributed to the lack of access to EPI ...
Biosimilar’s Growth in Pharmerging Markets: An Analysis of the Regulatory Environments
(University of the Western Cape, 2020)
The introduction of biosimilars to health care markets across the globe has had some success
in increasing competition and improving the cost of healthcare. While savings are important
for driving the biosimilar uptake, ...
Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
(University of the Western Cape, 2020)
Neurodegenerative diseases (ND) are chronic and progressive in nature, and
characterized by the gradual loss of neurons in various regions of the central
nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's ...
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
(University of the Western Cape, 2020)
Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ...
Perceptions of the pharmaceutical industry and regulators in South Africa towards registration harmonisation in the Southern African Development Community (SADC)
(University of the Western Cape, 2021)
Medicines have to be regulated in an effort to monitor their quality, safety, and efficacy. The
process of medicines registration is lengthy, costly, and document-heavy. Many countries have
limited expertise and resources ...